Lisa Sullivan, PhD
Professor of Biostatistics
Boston University School of Public Health
This module introduces statistical techniques to analyze a "time to event outcome variable," which is a different type of outcome variable than those considered in the previous modules. A time to event variable reflects the time until a participant has an event of interest (e.g., heart attack, goes into cancer remission, death). Statistical analysis of time to event variables requires different techniques than those described thus far for other types of outcomes because of the unique features of time to event variables. Statistical analysis of these variables is called time to event analysis or survival analysis even though the outcome is not always death. What we mean by "survival" in this context is remaining free of a particular outcome over time.
The questions of interest in survival analysis are questions like: What is the probability that a participant survives 5 years? Are there differences in survival between groups (e.g., between those assigned to a new versus a standard drug in a clinical trial)? How do certain personal, behavioral or clinical characteristics affect participants' chances of survival?
After completing this module, the student will be able to:
- Identify applications with time to event outcomes
- Construct a life table using the actuarial approach
- Construct a life table using the Kaplan-Meier approach
- Perform and interpret the log rank test
- Compute and interpret a hazard ratio
- Interpret coefficients in Cox proportional hazards regression analysis