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Date or order number: 1921
Description: Bacillus Calmette-Guerin vaccine (BCG) is introduced; still used today outside the US

Date or order number: 1942
Description: Rene Dubos hypothesizes that "selectio" will occur due to use of antibiotics

Date or order number: 1944
Description: Streptomycin is introduced

Date or order number: 1948
Description: Para-amino salicylic acid (PAS) is introduced

Date or order number: 1951
Description: Isoniazid (INH) is introduced

Date or order number: 1956
Description: Resistance to streptomycin, PAS, and INH is found in Great Britain

Date or order number: 1957
Description: Rifampacin is introduced

Date or order number: 1962
Description: Ethambutol is introduced

Date or order number: 1970
Description: Widespread use of rifampin and INH; MDR-TB

Date or order number: 2006
Description: XDR-TB is identified

Date or order number: 2011
Description: 69 countries report at least one case of XDR-TB