Syllabus - EP713 Introduction to Epidemiology

EP713 Syllabus - Fall 2015

Note: We are continually trying to improve the accessibility and usability of our learning modules. Please forward comments and suggestions to wlamorte@bu.edu.

 

Link to Syllabus Contents

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 NOTE: The A1 section will meet in room L-112 in the instructional building, Most class meetings are on Mondays from 8:00-10:30 AM, except as noted on the course schedule.

 

 

Instructor:

Wayne W. LaMorte, M.D., Ph.D., M.P.H.

Professor of Epidemiology,

Talbot 422, East wing

Office phone: (617) 638-5073      

e-mail: wlamorte@bu.edu

 

Teaching Assistants:

Tali Cassidy cassidyt@bu.edu Students with last name A through Mc

Kaylie Patrick kap92@bu.edu Students with last name Mi through Z 

 

 

 

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Course Objectives, Goals, and Structure

Course Objectives

Epidemiology is a discipline that identifies the determinants of defects, disease and injury in human populations and provides a means of assessing the magnitude of public health problems and the success of interventions designed to control them. Epidemiology is universally regarded as a discipline that is essential for understanding and solving public health problems, regardless one's area of concentration or specialization. The Council on Education for Public Health (CEPH) states that, "A professional degree is one that, based on its learning objectives and types of positions its graduates pursue, prepares students with a broad mastery of the subject matter and methods necessary in a field of practice; it typically requires students to develop the capacity to organize, analyze, interpret and communicate knowledge in an applied manner. " Accordingly, BUSPH has enumerated specific competencies in epidemiology based on the competencies identified by The Association of Schools of Public Health (ASPH). All MPH graduates are expected to mastered these competencies regardless of their area of concentration.

Course Goals

  1. To introduce the basic principles and methods of epidemiology and demonstrate their broad applicability to public health.
  2. To provide fundamental skills needed to interpret and critically evaluate literature relevant to public health professionals.
  3. To provide a structured method for organizing and analyzing raw data and to enable you to interpret and communicate the results to public health professionals and to the general public.

In addition, each module has specific learning objectives that explicitly state the concepts and skills you will be expected to master. Achievement of these learning objectives is essential not only for successful completion of the course, but also for you to function effectively as a public health professional.

Course Structure

The course is designed with a mixed format that includes lectures, homework assignments, independent learning exercises, and in-class problems and discussion. The lecture segments are designed to establish a foundation for concepts, principles and skills. Homework assignments provide opportunities for active learning that are essential to mastery. Several topics will be covered not by lectures, but by independent learning exercises in which fundamental content is provided by the online modules, by the textbook, and by other readings, and structured exercises will provide opportunities for active learning and discussion. Attendance is required for all classes; you are responsible for all material presented in class.

Course Components

Since students differ in their preferred learning style. Many are visual learners, but others prefer textbooks or lectures, and some prefer to learn through solving real problems. Probably most of us rely on a combination of learning styles. In recognition of this I have tried to present course materials in several ways that emphasize different learning styles. While the actual classes would best be described as lectures, they incorporate a variety of techniques including visualization of concepts, in-class problems, small and large group discussion. I have designed the class to combine clear explanations of key concepts with opportunities for active learning and mastery of skills. I would strongly encourage you to attend classes.

Graded Homework Assignments

I. Pre-Class Quizzes

You are expected to read the online, interactive web pages before you come to class in order to decrease the amount of "content delivery" by straight lecture. This makes it possible to utilize classroom time for more active learning that will include problems and discussions. To achieve this it is essential that you work through each online module before the corresponding class. In order to encourage you to do this, there is a short "pre-class quiz" each week consisting of five questions. These are "open-book" quizzes that generally consist of five questions that can be answered by thoughtfully reading the module. You are expected to complete these on your own. The pre-class quizzes may be taken only once and they must be submitted before the class that discusses that topic.

II. Post-Class Quizzes

Homework is intended to reinforce concepts, to identify misconceptions, and to provide practice questions that are very similar to what will be found in the exams, although you will be expected to show your calculations on exams, and exams will also include open-ended questions (e.g. List four advantages of cohort studies). Unlike the pre-class quizzes, the post-class quiz questions are randomly drawn from a pool of questions on a given topic. When you begin a post-class quiz on a given topic, Blackboard randomly selects 10 questions from the pool of questions on that topic. The post-class quizzes are also "open-book", and the are not timed, but you should complete them in a timely manner so that the system doesn't suspend or "time-out" on you. You are expected to work through the post-class quizzes on your own. However, if you are having difficulty with a question, you may ask the instructor or the Teaching Assistants for help on the related topic, but not  the answers to specific quiz problems. You must complete and submit the post-class quiz for a given topic at least once during the week following the class discussion of that topic and before the next class. However, unlike the pre-class quizzes, the post-class quizzes may be taken as many times as you like; each time you take a quiz, Blackboard will randomly select 10 questions from the relevant question pool . The last score achieved on a post-class quiz will be used to compute your semester quiz grade.

NOTE: Approximately 20-25% of the questions on the midterm and final exams will be taken from the post-class quiz pools. Therefore, it may be to your advantage to take a given quiz again even after achieving a good score. This strategy would enable you to see more of the questions that will appear on the exams, and it will give you additional practice. There is little down-side to this, because if you get a lower score, you can always take it again until you get a high score.

Reviewing past quizzes and feedback:

After your quizzes have been submitted and graded, you can still review them to see what you got wrong and what the feedback was. To review, go to Blackboard.bu.edu to the "Tools" section, and click on "Check Your Grade". You should see a table that summarizes all of your quizzes and test grades. (Ignore the total score; this is meaningless.) To review a quiz click on the score for that quiz, and you should be able to see how you answered, what the correct answer was, and what the feedback was (if any).   

III. Pass/Fail Data Analysis Assignments

You are required to complete two analyses of raw data sets:

  1. Effect of Low HDL Cholesterol (HDLC) on Coronary Heart Disease in the Framingham Heart Study. (A prospective cohort study)
  2. Effect of Smoking on the Need for Femoral Artery Bypass Surgery (A case-control study)

For each of these assignments there is a folder posted in the Assignments section of Blackboard. The respective folders contain:

  1. A video on how to conduct the raw data analysis using Excel. The video is very detailed and walks you through the steps.
  2. A detailed set of instructions regarding what you are required to submit.
  3. The raw data set in an Excel file.

You are required to complete these assignments independently, i.e. you must do the analysis yourself. For each analysis, watch the video (which will walk you through how to do the analysis); then conduct the analysis, and summarize your findings as described in the detailed instructions. Use a second Worksheet in the raw data file that you analyzed to paste your analysis from EpiTools.XLS and your interpretation of the analysis. When you are done, save your Excel file using your name in the file name, e.g., Myfirst-Mylast-analysis1.XLS and send it to your to your teaching assistant as an email attachment. NOTE: Do NOT send a ZIP file.

This is a required Pass/Fail assignment. If you have questions about how to conduct the analysis, you may ask your TA or the instructor for help.

The online grade book on Blackboard will include a column for each of these assignments. If a "1" appears, it indicates that the assignment was completed satisfactorily. A "0" indicates that it was graded and found to have deficiencies that need to be corrected. If there is neither a "0" nor a "1", it indicates that the assignment has not been received, or it has not yet been graded.

If your analysis is incorrect, you will be notified by your TA, and you will be given an opportunity to correct any mistakes. Nevertheless, each student must successfully complete this assignment in order to demonstrate mastery of this skill. If you do not successfully complete both pass/fail assignments, you will receive a grade of "Incomplete" for the course.

Questions and Help

If you have questions or don't understand something, please ask. You may interrupt and ask questions at any time during class. I have also reserved the classroom for the hour before class as a help session. I will generally arrive at class an hour early for extra help and to answer questions, and I will be happy to stay after class as well. You may also call my direct office phone line at any time, and you may also email questions to me. I check my email frequently, and I will generally answer email questions promptly. You may also arrange to meet with me for additional help. I do not have fixed office hours, because your schedules are so varied. However, feel free to email to set up a meeting for additional help. Again, if you are struggling with something, please ask promptly.

Tutoring Service for MPH Candidates

There is a free tutoring service for MPH students taking core courses. If you are struggling with the course, you should ask for help early and often, and utilize all of the many resources, including the Teaching Assistant, the instructor, and the tutoring service. The tutoring service can be contacted at sphtutor@bu.edu. If you are struggling with the course, ask the instructor to refer you to the tutoring service.

Exams and Semester Grades

Semester grades will be based on the following:

 

Additional Notes:

Computation of Semester Average

The grades entered into the online grade book in Blackboard will be downloaded into an Excel spreadsheet, and a formula reflecting the weights outlined above will be used to compute the overall semester average for each student. This average will be rounded off to two decimal places, and letter grades will be assigned according to the table below. Also note that grades of "A" or "A-"are generally earned by less than half of the class.

A

94.00-100

A-

91.00-93.99

B+

89.00-90.99

B

82.00-88.99

B-

80.00-81.99

C

70.00-79.99

60.00-69.99

F

<60

Minimum Grades

EP713 has a minimum grade requirement of:

If you feel you are in danger of failing to meet the minimum grade requirement for your program as you progress through the course, please speak to the instructor about resources that might be available to you, including the free core course tutoring program for MPH students. 

At the conclusion of the semester, students with extenuating circumstances that prevented them from meeting the required minimum grade may contact the instructor to request an opportunity to remediate a specific portion of the course in order to demonstrate mastery of material on an additional final exam.  The additional final exam must be completed prior to the start of the next semester.  This remediation option applies only to EP713, and the vast majority of student with grades below the minimum requirement will not be allowed this remediation option.  The decision regarding whether the student will be allowed this option is entirely at the discretion of the instructor.

Students who fail to achieve the minimum grade requirement for their degree program at the conclusion of the course must retake the course in the next semester it is offered and should contact the Registrar's Office not more than 14 days after the final class to arrange the retake.

See also:

Attendance and Classroom Environment

You are expected to attend all classes. I have tried to present the course content in a variety of formats to suit several learning styles; nevertheless, classroom activities are an important component of the course. Experience has shown that students who attend classes regularly tend to achieve high grades, while students who attend irregularly do not.

I expect the classes to provide an atmosphere of mutual respect. All of us should be able to express our ideas and views even when they conflict. All of us should listen respectfully. This requires that side conversations unrelated to classroom activities should take place before or after class. In addition, cell phones should not be used in the classroom. If you have an emergency and must use your cell phone, please leave the classroom.

Use of Laptops, Tablets, iPads, Smart Phones, and Other Electronic Devices in Class

I regard the classroom as a sanctuary for thoughtful discussion of concepts, ideas, and problems related to public health. A key element of this discussion is mutual respect among students and instructors. Laptops and other devices connecting to the Internet are allowed in my classroom (but not during exams) provided they are used only to enhance the teaching environment. By this, I mean that students are encouraged to utilize course materials, to take notes, and to research relevant topics on the Internet. However, these devices may not be used for purposes unrelated to this class; emailing, use of social media, playing computer games, and other uses unrelated to the course are not allowed. These practices are disrespectful to me and to other students, and they are distracting and disruptive. Many students have complained about this to me. Therefore, these trivial uses that are unrelated to course activities are not allowed. If you absolutely must use Facebook or play computer games when the class is in session, then don't come to class. If you engage in these unauthorized uses during class, you will be asked to leave.

Course Schedule - Assignments, Classes, and Exams

PRE-Assignment (before the first class)

  • Read the entire Syllabus carefully.
  • Study the online module on the Evolution of Public Health and Epidemiology, and submit Discussion #1 on Flu Vaccination to the designated Discussion Forum on Blackboard. Instructions for the discussion are inside the online module on Evolution of Public Health. The discussions will be graded using the rubric described in the Syllabus.
  • Study the module on Descriptive Epidemiology. and the module on Surveillance
  • Complete pre-class quiz #1 on Descriptive Epidemiology. This is a short "open book" quiz.
  • Scan the abstract by Gottlieb et al. on Pneumocystis Pneumonia from New England Journal of Medicine). Just get a feel for this important piece of 'descriptive epidemiology.'

OPTIONAL:

  • Reference: Chapters 1 & 5 in Aschengrau & Seage
  • For fun, see http://ocp.hul.harvard.edu/contagion, a web page entitled "Contagion: Historical Views of Diseases and Epidemics.")

Class 1 - 9/14 - Descriptive Epidemiology

 And Discussion: How does one decide whether to get a flu shot?

Due Before the Next Class:

  • Study the online module entitled "Overview of Analytic Study Designs".
  • Complete pre-class quiz #2.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 6 (Overview of Epidemiologic Study Designs)

Class 2 - 9/21 Overview of Analytic Studies

 

Due Before the Next Class:

  • Complete and submit post-class quiz #1 on Study Designs and Descriptive Epidemiology..
  • Study the module on Measures of Disease Frequency.
  • Complete pre-class quiz #3.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 2. (Measures of Disease Frequency).

Class 3 - 9/28 - Measures of Disease Frequency:

Counts, Prevalence, & Incidence

 

Due Before the Next Class:

  • Complete and submit post-class quiz #2 on Measures of Disease Frequency.
  • Complete pre-class quiz #4.
  • Study the module on Measures of Association.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 3: pp. 59-69; Chapter 9: pp. pp 247-249.

Class 4 - 10/5 Measures of Association

 

  • Complete and submit the post-class quiz on Measures of Association
  • Study the module on Random Error.
  • Complete pre-class quiz #5.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 12: pp. 307-321 & 330-338.

10/12 is a Holiday; class is moved to Tuesday

Class 5 – 10/13 (Tuesday) - Random Error

Evaluating the Role of Chance

 

Due Before the Next Class:

  • Complete and submit the post-class quiz on Random Error.
  • Study the module on Intervention Studies (Randomized Clinical Trials)
  • Complete pre-class quiz #6.on Clinical Trials
  • Read the abstract and the methods sections in the paper by Ridker et al. on low dose aspirin to prevent heart disease in women. N. Engl. J. Med. 2005;352:1293-304. http://content.nejm.org.ezproxy.bu.edu/cgi/reprint/352/13/1293.pdf)

 

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 7 Experimental Studies) & Chapter 17 (Ethics in Research Involving Human Participants)

Class 6 - 10/19 - Intervention Studies

(Experimental Studies, Clinical Trials)

 

Due Before the Next Class:

  • Complete and submit the Post-Class Problem Set (quiz) on Intervention Studies (Clinical Trials).
  • Study the module on Cohort Studies.
  • Complete pre-class quiz #7.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 8.

Class 7 - 10/26 - Cohort Studies

 

Due Before the Next Class:

  • Complete and submit the post-class quiz on Cohort Studies.
  • Complete the 1st Pass/Fail assignment: Effect of Low HDL on Heart Disease in the Framingham Heart Study (See instructions under 'Pass-Fail Assignments'.)
  • Study the module on Bias.
  • Complete pre-class quiz on Bias.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 10

 Class 8 - 11/2 - Bias 

 

Due Before 11/9 (the Midterm Exam):

  • Complete and submit the post-class quiz on Bias.. Note: In order to complete the Quiz on Bias, you will need to read the methods sections from three papers in order to determine whether bias could have affected either of these studies. You do not need to read the entire paper. Read:
    • Perneger et al.: NSAIDS and renal failure
    • The abstract and the methods section of the paper by Ridker et al. on low dose aspirin to prevent heart disease in women. N Engl J Med 2005;352:1293-304. http://content.nejm.org.ezproxy.bu.edu/cgi/reprint/352/13/1293.pdf
    • Read Manson et al.: A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N. Engl. J. Med. 1999;341:650-8. http://content.nejm.org.ezproxy.bu.edu/cgi/reprint/341/9/650.pdf

Extra Class on Screening for Disease - Thursday 11/5 from 12:00-12:50 in Room L-112

 

Before this class, your should:

  • Study the module on Screening for Disease.
  • Complete the pre-class quiz #11 on Screening.

 

Tali Cassidy will discuss Screening for Disease.

 

Class 9 - 11/9 - Midterm Exam

(In class exam; no notes, books, PDAs or other electronic devices; simple, non-programable calculators are ok)

 

 Due Before the Next Class:

  • Study the module on Case-Control Studies.
  • Complete pre-class quiz #9 on Case-Control Studies.
  • Complete and submit the post-class quiz on Screening.

 

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 9.

Class 10 - 11/16 - Case-Control Studies

 

Due Before the Next Class:

  • Complete and submit the post-class quiz on Case-Control Studies.
  • Review for Midterm Exam

 

 

Due Before the Next Class:

  • Complete the 2nd Pass/Fail assignment: Effect of Smoking on the Need for Femoral Artery Bypass Surgery (A case-control study) (See instructions under 'Pass-Fail Assignments'.)
  • Study the module on Standardized Rates.
  • Study the module on Confounding.
  • Complete the pre-class quiz on Standardization and the pre-class quiz on Confounding.

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 3: pp. 69-73 (Direct Standardization), Chapter 11 (Confounding)

Class 11 - 11/23 - Direct Standardization and Confounding

 

Due Before the Next Class:

  • Complete and submit the post-class quiz on Standardization.
  • Study the module on Multivariable Methods

OPTIONAL:

  • Reference: Aschengrau & Seage, Chapter 13 (Effect Measure Modification).

Class 12 - 11/30 - Effect Measure Modification; Regression Analysis to Control for Confounding

 

Due Before the Next Class:

  • Complete and submit post-class quiz on Confounding.
  • Read the module on Critical Review of Papers and Presentations
  • Read the module on Causality.(no pre-class quiz on Causal Inference)
  • Read the assigned papers on the whether eating fish or taking fish oil supplements decreases the risk of coronary heart disease..Determine whether the conclusions are valid, and make notes regarding limitations of the studies with regard to random error, bias, or confounding.

 

Class 13 - 12/7 - Causal Inference

 

 

  • Review for Final Exam

 

Class 14 - 12/14 - FINAL EXAM

 

(In class exam; no notes, books, PDAs or other electronic devices; simple, non-programable calculators are ok.)

 

 

Learning Objectives by Topic Area

History of Epidemiology

After successfully completing this unit, the student will be able to:

Descriptive and Scientific/Analytic Epidemiology

After successfully completing this unit, the student will be able to:        

Cross-sectional studies

After successfully completing this unit, the student will be able to:

Ecologic studies

After successfully completing this unit, the student will be able to:

Measures of Disease Frequency

After successfully completing this unit, the student will be able to:

Measures of Association

After successfully completing this unit, the student will be able to:

–   Cumulative incidence ratio

–   Cumulative incidence difference

–   Incidence rate ratio

–   Incidence rate difference

–   Attributable proportion/fraction

–   Population attributable proportion/fraction

Random Error

After successfully completing this unit, the student will be able to:

Research Ethics [OPTIONAL]

NOTE: This unit will be completed as an independent learning module supplemented by an online discussion of a controversy dealing with research ethics, followed by a directed in-class discussion.

After successfully completing this unit, the student will be able to:

Intervention Studies (Experimental Studies, Clinical Trials)

After successfully completing this unit, the student will be able to:

Cohort Studies

After successfully completing this unit, the student will be able to:

Case-control studies

After successfully completing this unit, the student will be able to:

Bias

After successfully completing this unit, the student will be able to:

Confounding

After successfully completing this unit, the student will be able to:

Effect Measure Modification

After successfully completing this unit, the student will be able to:

Screening for Disease

After successfully completing this unit, the student will be able to:

Causal Inference

After successfully completing this unit, the student will be able to:

Academic Policies

BUSPH Policy on Academic Misconduct

Academic misconduct is any intentional act or omission by a student which misrepresents his or her academic achievements, or attempts to misrepresent these achievements. While not an exhaustive list, the following acts constitute academic misconduct:

Charges of academic misconduct will be brought to the attention of the Associate Dean for Education, who will review all such cases and decide upon the appropriate action. A student who is found guilty of academic misconduct may be subject to disciplinary action, up to and including dismissal from the School. See Policy on Academic Misconduct.

Plagiarism Tutorial

The Alumni Medical Library has created the BUSPH Plagiarism Tutorial, which can be found at http://www.medlib.bu.edu/tutorials/.  This link also includes additional resources and tutorials for students.  Please see the following Student Insider post for full details and login instructions for students http://sph.bu.edu/studentinsider/Required-Reading/new-plagiarism-tutorial-for-student-review.html.

BUSPH Policy on Timely Completion of Course Requirements

All students are required to take examinations on the day they are scheduled and to hand in assignments no later than the due date. Syllabi should indicate examination dates and project (which includes papers) due dates, and penalties associated with late submissions of assignments. If a student cannot take an exam or submit a paper or project on time, the student must request an alternate date in writing from the faculty member. The request for extensions should only be approved if the student has encountered a serious problem that arose unexpectedly and that will make it impossible or extremely burdensome for the student to take the exam or fulfill the assignment requirements as scheduled.  In such a circumstance faculty may grant a request for an alternate exam or due date.  Substitute examinations should ordinarily be scheduled as soon as possible after the scheduled exam date. Students should be warned that if they request a delay in taking a final exam or in completing a final assignment they may receive a grade of "incomplete."

It is the student's obligation to request an extension prior to the time of the exam or date an assignment is due. Only in circumstances when it would be impossible or extraordinarily burdensome for a student to make the request prior to the scheduled date may the faculty member consider a request for an extension of time after the date of the exam or assignment due date.

Faculty may require a student to provide documentation of the circumstances the student submits as the reason for granting an alternative exam or due date, such as a note from a physician. 

A student's failure to adhere to this policy may result in a failing grade being granted for the exam or paper.

Disputes between faculty and students arising out of this policy will be decided by the Associate Dean for Academic Affairs.

See Policy on Timely Completion of Course Requirements.